I ran a 55 gallon malawi mbuna tank with a penguin 350 for a while. It worked, but not great. The filter pads got full pretty quickly. If you want only HOB filters, go for 2 of them.
Then, I added a Rena XP3. The combination worked GREAT. Eventually, I went to only the XP3, to reduce overall noise. That's what I ran for 6 months.
Now, I have a 75 gallon, with the XP3 and an Eheim 2217. They keep it nice and clean. (and quiet)
Broham - for a 125, you need two canisters or a large canister and HOB. I've even seen people do 3 HOB's on 125's too. Either way, you want more than one.