We have been treating our fish for 5 days now with Aquari-Sol for Ick. On the bottle it does not say anything about doing water changes during the medication period. Some things I have read on the net say to do water changes, others don't mention it. The only difference I have notices when doing the testing of the water daily is that our nitrates have now gone up to between 20 and 40 from 10 a couple of days ago. The ammonia and nitrites are still at zero. We are going to do a water change of 50% now and then remedicate the water and add the additional salt. We do have our temperature up to 85 degrees. Is there anything else we can do to cure this, we have already lost 2 bristlenose and don't want to lose our pitcus catfish too.