you can keep anything with 400s and you can also keep anything with 250s. But both semi-limit you to where you can keep things. You can definatly keep lower lighting corals with 400s, ESPECIALLY in a tank that big. I would keep softies, mushrooms, and even a few leathers in my 40 breeder (only 16 inches deep... 14 including sandbed) right off to the side under a 400 watt halide and t5s. You jsut have to acclimate your corals. ANd trust me, once acclimated, most of them will look much better under the much higher lighting. ANd if not, you always have sides and a very deep tank to put things in. As far as higher lighting corals, it really depends. The 400s will make different types of sps look much better too, especially if you run the 20K bulbs. But if you dont plan on keeping a lot, if any, then the 250s would be perfectly fine, as you woudl still have the option of keeping them and haveing them do well as long as they are higher up.