I just switched the gravel in my 55gal tank. I took out half and put in the new stuff, then two weeks later I switched over the rest of it. I didn't get any spikes, but this tank is part of a larger system so that lends some extra stability. I would say even if you do one half then a week later do the second, you should be fine, just keep an eye on ammonia for a day or two after the changes and do water changes if you get a mini-cycle, but it shouldn't be too bad.