When nitrates get above ~40ppm my Tiger Barbs start standing on their heads. Other fishes get restless, pacing up and back along the glass, in stereotyped action.
Surely, fish don't seem to turn pale and float belly-up to the surface as soon as nitrates get over 40ppm...
but a rising end-product that you can easily measure suggests that there may be some other rising end products that you can't so easily measure.
In my planted tanks, I've found that light dosing with potassium chloride has enabled my plants to reduce nitrates to <20ppm. For me, that's a symptom of a system that's in balance.