Nothing make ammonia less toxic. Ammonia kills fish...period. Biospira is basically a bag of bacteria that normally takes the fish tank a few weeks to grow. You introduce it at the same time as the fish and it's supposed to cycle the tank instantly. Although it doesn't always work properly. I got HUGE nitrite spikes after a few days with it but as long as you test the water every morning & night and do a water change if there is any ammonia or high nitrites it will work good.