" "Cycle" is an all natural product, which releases massive amounts of benficial bacteria into the aquarium, it is impossible to overdose" That is what the bottle boasts. In my experiances, Biospira is made for overnight cycling and such, Cycle is more meant for helping to reduce ammonia/nitrite levels and such while introduceing new fish, and to make newer aquariums more 'mature' and less stressful through weekly maintence while adding cycle. I have used both products and was quite pleased with the results in both, although i wouldnt recommend using "Cycle" to try and immediatly make a brand new aquarium useful/safe for fish. I do use it whenver i do more than a 30% water change, or when doing a more advanced cleaning of the tank, as well as whenever i add more than 2 fish. the larger bottles when used as the directions state do last quite a long time, and at my LFS you get a decent deal for buying the bigger ones. just my 2 cents worth