I wouldn't think so. Can I ask from what color are you changing to what color? What kind of decorations and such do you have in there? If you don't have live plants, it really shouldn't be a difficult task. What is the current depth? The only problems I can think of is 1.) if you really don't have much depth to begin with, you'd be losing a lot of beneficial bacteria and such that call your substrate home and 2.) if your replacing a large grained substrate (ie pea gravel) with a small grained one (ie pool filter sand), the small grained one will eventually work it's way to the bottom and you'll be stuck with the same gravel that you wanted to replace on the top again. That is not an overnight process, but it will eventually happen