Today after work I went and got some Bio Spira due to slow cycling. I read on the package that some water conditioners can kill the bacteria, and was wondering if Prime is one you have to worry about, as this is what I use. Also, do I need to wait any length of time before doing PWC's? I just want to make sure I don't mess up the Bio Spira because I am really ready to have a cycled tank!! Thanks! 