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Symptoms in fish
The main symptoms of fish tuberculosis are loss of scales, loss of color, lesions on the body, wasting, and skeletal deformities such as curved spines.
Diagnosing
Looking a slides of infected tissue under a microscope is sometimes enough to recognize Mycobacterium marinum, but in most cases a bacterial culture will be necessary. Both Mycobacterium tuberculosis and Mycobacterium marinum are acid fast, which means that they stain bright pink against a blue background.
Treatment
Treating fish tuberculosis is really difficult and euthanizing the fish a probably less painful for the fish than forcing it to go through endless treatments that may not have any effect on the disease. Euthanizing all the fish in the infected aquarium is also the best way of preventing the disease from spreading.
If you decide to try and treat your fish, keep in mind that Mycobacterium marinum can infect you as well. The risk of being infected can however be decreased dramatically by following a few simple safety guidelines. You can read more about this further down in this article.
Fish can be treated with the same drugs as humans get when they become infected by Mycobacterium marinum, e.g. Kanamycin. Since this is a very resilient microbe, normal treatment involves administering at least two different medications over the course of at least three months.
A lot of aquarium problems can be fixed by performing frequent water changes, increasing the water temperature and adding some salt to the water, but fish tuberculosis is not one of them. Raising the water temperature may even worsen the problem since Mycobacterium marinum prefers warm water (their ideal temperature is 30°C).
Prevention
Since curing fish is virtually impossible once the disease begins to manifest, preventative measures are highly important.
Keeping your fish healthy, happy and well-fed will boost their immune system and make it possible for them to handle limited exposure to Mycobacterium marinum.
Wounded or otherwise weakened fish should be moved to quarantine tanks where they can be treated and given time to recuperate, since weak fish that is left in the main aquarium can serve as a breeding ground for all sorts of malicious microorganisms that may eventually grow numerous enough to attack even the healthy fishes.
New fish should ideally be quarantined before you allow it into you main aquarium. Plants, substrate, equipment etcetera should be sterilized to kill of potentially harmful bacteria before being introduced to the aquarium. See the plant section for more info about how to sterilize plants without causing injury to them.
An aquarium that has had an outbreak of fish tuberculosis should be meticulously cleaned out with bleach and left to dry before you restock it.