I was wondering only because I have a betta sorority 30 gallon with about 5 bettas, and I noticed DPs have similar parameters. I noticed a few sites suggesting that DPs are only nippy when they are underfed, and I have plenty of snails to feed them.
I think it would depend on the personality of the puffer. In a tank that big it might be worth a try, but have a backup plan ready. Is the tank heavily planted? That would likely help with aggression too.