I'm a big proponent of keeping it simple. I'm sure a lot of those supplements and stuff are good... many people with far more experience than me swear by them. But I, for one, have had a lot of luck keeping things as natural as possible. Good water, good salt, and regular, frequent water changes. The only thing I supplement is alk & Ca because I can't otherwise keep up with my livestock's needs.
I feel that the more stuff you're dumping into your system, the more difficult it will be to figure out what exactly went wrong when a problem does arise.