I think it depends on what you're shipping. Plants are going to tolerate an unheated 50F box a whole lot better than fish are. And a 50F day time temp can still swing down below freezing at night. So you've got to take nighttime temperatures into consideration too. Those packages go in cargo areas of planes, unheated processing facilities and unheated trucks at the wee hours of the morning when temps are still chilly. Also, try to find out what route the shipping plane takes. For instance, leaving sunny california headed to seasonal new jersey might find that the plane goes via chicago where temps are not so safe yet.