Yeah, I actually used bio spira to set up 3 tanks recently (about 15 days ago) and haven't had any problems. I used it in two ten gallon tanks and one 29, and each went through a period that lasted about two days where the water was kind of "milky." I assume that was just the bacteria blooming or something, and none of the fish seemed to be effected. In two of the tanks, I put the fish in the day after I added the bio spira, and in the third, about five days. All of the fish are still doing fine.