In a tank that big, separating mechanical and biological filtration is a real plus, unless you go with a sump system that does both.
I have a 180 that is moderately stocked (it used to be lightly stocked, but my kennyi have bred like rabbits...) and I use 2 prefiltered HOT Magnums, a prefiltered Eheim 2228 Professionel (packed with Ehfimech only) and an Eheim 2229 wet/dry packed with Ehfimech and plastic bioballs.
Until the kennyis got out of control, the filtration was just about right. For a 100, I'd go with a couple HOT Mags for mechanical filtration and large canister (e.g., Eheim 2028) packed for bio-only.
You could go with some big HOT filters (e.g. Emperor 400s or Aquaclear 500s), but I prefer canisters on a tank that big.
Jim