Although have drilled many tempered glass tanks, if you are not comfortable with such procedure, over flow prefilter box is not that risky as we used to depended on such prefilters for long time.
Only drawback on prefilter is that collection of air bubbles (reduces amt of water being drained) on top of U-Tube which can be easily modified to eliminate the all the bubbles collecting on top of U-tube with check valve and air tubing. New models may have such thing already built-in.
Apply TWO prefilter boxes, a back up to each other in case one fails or being maintained/cleaned.
As far as canister filters, I always felt that it would become nitrate factory when it is not cleaned often. If you can maintain it properly, why not?? as I am using one on my local collection of s/w fishes.
Ive tried reef/fowlr with nothing but PH, PS and of course massive amt of LR, but required more physical work from time to time. Before mulms buld too much in the tank, I would hook up Quick Filter Cartridge on the PH temporarily which kept tank sparkling CLEAR.
Utilizing sand shifting/burrowing stars, sea cucumbers and Gobys also assisted in prevention of mulms.
I feel that not all will have same outcome as results are depended on many factors.
No matter how many PH I ran, blowing in all different directions, there always seeems to dead spot where mulm will accumulate. Put some food in there and you will see some will land/collect in dead areaS.
Hope all goes well.