Silica is fine (that's just sand). Alumina would worry me... Aluminum leaching into the water could be bad. Don't know how much would actually leach though.... I know that a lot of people use Quikrete cement for 3D backgrounds, so at least it's not uncharted territory. I've been looking at the ingredients, and I don't see anything "harmful" per say, and no heavy metals at all. Alumina, which is made from Bauxite and used in aluminum metallurgy is the closest to metal in the mix. It's commonly used in production of ceramics, so nothing too out of the ordinary. Silica is in there too, but it's also in sand, which is commonly used as a substrate. Basically I don't think anything will leach out that is harmful aside from increased carbonate hardness and therefore an elevated pH.
I like the idea of sealing it with 2 part epoxy, then you don't have to worry.