Neither should present you with any problems. I have a 47 with a 2 tangs, flame, shrimp, and a manderine and they are doing very well. (Upgrade to 90-100 gal in the works) I would however recommend you look for a yellow in the small to medium size (2-3 inch) as with proper feeding it will grow. A large will most likely stress and die. Also if you don't have any naturally occuring algae keep some high quality dried sea veggies on hand. Tangs are grazers and will strip your tank of the green stuff in no time and they need their veggies. I feed a mix of veggies (soft boiled brocolli included) and brine which the angel chows on as much as the tangs. Make sure you have eradicated that ick before you add the yellow! Don't worry about the lonely cardinal. Many fish are schooling and do fine on their own in aquariums.