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olaf

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Jan 8, 2003
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Bullrout & Freshwater waspfish venom I think are similar. (Not sure)
An investigation of the biological activity of bullrout (Notesthes robusta) venom.

Authors

Dr S. T. Hahn
Ms J. M. O'Connor

Journal

Toxicon 38 (2000) 79-89

Institute of origin

School of Natural and Complementary Medicine
Southern Cross University
Lismore NSW Australia

Running title

Investigation of bullrout venom activity

Address

Dr Scott Hahn
School of Natural and Complementary Medicine
Southern Cross University
PO Box 157
Lismore NSW 2480 Australia
Telephone: 02 6620 3948
Fax: 02 6620 3647



ABSTRACT

Bullrout envenomation is known to cause intense pain. Crude bullrout venom and venom fractions were assessed for protease, hyaluronidase, phospholipase and haemolytic activities, reactivity with stonefish antivenom, lethality to brine shrimp and ability to elicit pain in human subjects.

Compared with venom obtained from frozen specimens, live fish venom milking techniques rendered greater venom potency and improved storage characteristics. Although mild proteolytic and haemolytic activity was observed, crude venom demonstrated no hyaluronidase or phospholipase A2 activity, did not effect brine shrimp, or show antigenicity with stonefish antivenom. A single venom protein isolated from bullrout venom is attributed with causing pain in human subjects. The sensations elicited by this novel algesic protein are consistent with chemical stimulation of polymodal nociceptors.

http://www.scu.edu.au/schools/ncm/staff/scott/bullrout.html
http://www.scu.edu.au/schools/ncm/staff/scott/bullrout.pdf

History:

Pain
Immediately excruciating and incapacitating localized pain follows a sting from members of the Synanceia (stonefish) genus.
This pain may spread to involve the entire limb and regional lymph nodes, peaking at around 60-90 minutes and lasting up to 12 hours if untreated.
Mild subsequent pain may persist for days to weeks.
Less severe, although extremely painful, symptoms are seen following envenomation with members of the Scorpaena (scorpionfish) and Pterois (lionfish) genera.
Physical: The severity of envenomation depends upon multiple factors including the offending species, the number of stings, and the age and underlying health of the victim. Scorpaenidae stings are progressively more severe from Pterois (lionfish) to Scorpaena (scorpionfish) to Synanceia (stonefish).

Puncture wound
Classic envenomation reveals one or more puncture wounds, each discolored by a surrounding ring of bluish cyanotic tissue.
Subsequent edema, erythema, and warmth may involve the entire limb, although it rarely results in tissue necrosis in the absence of secondary infection (in marked contrast to stingray envenomation injuries).
Vesicle formation, particularly of the hands, may be followed by rapid tissue sloughing, cellulitis, and surrounding hypesthesia.
Systemic effects may be present (eg, nausea, muscle weakness, dyspnea, hypotension).
 
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