maybe...
Co2 will add acids to the tank, this can use up the buffer (KH) and lead to a pH crash.
It is also possible to overdose the CO2, find a CO2 chart and locate your pH and KH, when you add CO2 you will move along the KH line to a new pH and a new CO2 level. If you add too much Co2, going too far along this line, you enter dangerous territory where fish can die.
DIY CO2 is harder to turn down than pressurized CO2, so you have to start small and increase if needed. The Hagen system is OK for 20 gallon tanks, I have that on my 20 and my 10. It can be turned down, sort of.
DIY CO2 is harder, you have to change out the mix to reduce the rate, or change the surface agitation or filteration to allow more CO2 to gas out. If you have a HOB filter, you probably can't OD the CO2 unless you really tried, but a cannister filter has less agitation at the surface, more CO2 stays in. It is all about balance, that is why each tank is unique.