Nah. I have mine in with fish from India and Thailand. I don't think that's a problem. My SAE's, being wild caught, are the only fish that could pontentially introduce a disease from the wild. Otherwise, my zebra loaches, harlequin rasboras and honey gouramis were captive-bred. It would be possible for the angels to encounter some disease that they can't handle but, given that most fish that they're likely to be housed with are captive-bred, I think it would be unlikely.