It really depends on your overall setup and arrangement, as well as stocking.
Do you have either a canister or hob filter on one end of the tank to collect the debris?
What kind of fish are you keeping in the tank, and how much cover is available for them to get out of the current?
I have an aquaclear 110 powerhead lying around that pumps a max of 900+ gph. My largest tanks are 75's, so I don't use it much or often. However, when I stir up a mess of pleco poop (3 L-204 Panaques) siphoning the tank that powerhead and a quickfilter attachment will make the water crystal clear again rather quickly.
One of my 75's has an aquaclear 110 hob filter on the left end of the tank, an aquaclear 70 powerhead and quickfilter on the same end to help circulate water, and an aquaclear 30 (also w/quickfilter) along with a Koralia nano on the right side to complete the flow pattern. Between the hob and the quickfilters there is very little debris on the sand in spite of all the rocks and driftwood in the tank.