two different threads here
Slipknottin seems to be focussed on the support value of the center brace for resisting gravity. This is not the primary purpose of the piece. The brace simply keeps the two long sides of the tank from separating with the outward force of water. The full weight of the water presses out as well as down. I agree that the silicon seal across the bottom helps resist this more than the air across the top, making the top brace indispensible, but that does not make the bottom one useless. Silicon has some adhesive properties, but without the top and bottom frames, we would quickly learn how much help it needs.
Remove the bottom brace and the center of the long sides at the bottom will want to push out. If successful only a little, a leak could happen and that nightmare that wakes you up with a cold sweat could be reality. It is simply a risk not worth taking. If you cannot replace the brace, securely nail or screw a stop block to the stand snugly on the center of the front and back of the tank stand to resist the force. Relying on silicone to do the job is like asking - sorry, excellent analogy escapes me - it is just the wrong material for the job.
I am willing to change risk water spillage when changing hoses etc, but total catatrophe is too much risk for your home and fish.