Sure, if you're so inclined. I have sand substrate in my 125 so I do my water changes out of the display tank so I can vacuum, but lots of people do their water changes out of the sump.
25% of the tank volume is the desirable minimum with 33% being the preferred volume.
Please note that the fabrication of the sump with respect to the flow paths and filtration processes is critical to the appropriate functioning of the sump.