I built my reactor from the plans at Rex Griggs' site. The reactor is oriented vertically. My output line from the canister goes into the top of the reactor. My return to the aquarium exits the bottom of the reactor. My co2 line enters the reactor about 1/4 of the way down from the top of the reactor. The water flow through the reactor is DOWN through the bioballs. This allows more contact time with water/co2 and I get very little waste of co2 this way. I have a 125g and since I went to this reactor set-up my co2 usage was cut in half, because I was wasting so much trying to mist co2 in the aquarium.
Mark
Mark