I always multi-filter, have for years/decades now. My mechanical and biofilters are separate so that I can rinse the mech frequently (at least weekly in FW, daily in salt) including the prefilters for the bio-only canisters. Keep your biofilter clean (remember, it works only on dissolved materials) and clean your mech as frequently as possible to reduce the bioload. Works for me, and quite a few others.
All-in-one filtration sounds convenient, but after keeping a lot of tanks alot of years I realized that it is not, it is a PITA and much more work than division of filtration by the nature of what you want to accomplish.
As sintered glass is not a permanent medium (despite many maufacturer's claims to the contrary - at least Eheim is honest about it), I have not tested that many brands that are still on the market so cannot answer your shedding question.