It would be nice to see a "biological booster" product that comes complete with a shelf life and perhaps a temperature sensitive sticker on the bottle that would indicate if the product had been time/temperature abused. I would tend to trust a company with legitimate ethics like that. But lets face it, if biospira was such a great product it would still be manufactured. Marineland opted to halt production due to marginal success rates.
I thought it was over something internal between Dr. Tim and the company (or something along those lines) and not because of the product itself.
I used biospira when I first setup my 30 gallon and it worked well...but I want to say it was sometime in the spring and it was refrigerated as was recommended.