You could do that, but I would advise against the use of the Bio Wheels themselves. They tend to become nitrate factorys. On top of my powerheads, skimmer, and live rock that I use for filtration I also have an Emporer 400 Bio Wheel filter that I use for added water movement and phospate removal if needed. With my Emporer I took out the Bio Wheels so it is just a big box with a spray bar for some added water flow. This allows me to move more water and put in some filter media to help with the water quality if needed.
Bradd
Bradd