The more I read about Columnaris, the more I think that this is exactly what I have in my tanks - all three of them. The description fits perfectly what I observed with my pandas. It fits the symptoms that the guppies show that die from time to time, usually after birthing stress. It fits how crappy my two remaining julii cories look, which never really recovered after that ich outbreak (or was it? They never showed any white spots). And it definitely fits the "saddle" one of my otos sports today.
I'm a bit at a loss what to do now. Isolating fish showing obvious symptoms is not really an option. I know the "keeping up water quality" part. But would you personally come with the antibiotics hammer for three tanks? Prolonged Melafix treatment? Anything else?