It depends on the species, different puffers thrive in different salinities. I would say no, as Dwarf Puffers will attack if they aren't stimulated. If you really want puffers I would get a 10 gallon for dwarf puffers, live plants, and oto catfish. Try sticking to 2-3 DP's, and a few otos for a 10 gallon. (These are all freshwater)
You could get a F8 in a brackish 20 gallon, with a few bumblebee gobies. Another otpion is a sole GSP in a 29+. (Both are brackish, although A FEW will tolerate freshwater)
You could get a F8 in a brackish 20 gallon, with a few bumblebee gobies. Another otpion is a sole GSP in a 29+. (Both are brackish, although A FEW will tolerate freshwater)