help asap please

Hmmm i'm not sure that there is alot you can do apart from do daily water changes for a bit and see if it helps also try getting him to eat some veggies as it might just be constipation which can also be a killer. Sorry i can't be any more help, you could try PM'ing barbie for advice as she is the pleco expert on here.
 
I think they are the same thing apart from one is stronger, it might be worth a try have you got a spare tank to pop him in so you can medicate?
 
API Melafix is antibacterial remedy for Fresh and Saltwater Aquarium Fish
Melafix rapidly repairs damaged fins, ulcers and open wounds
Melafix promotes regrowth of damaged tissues and fins
API Melafix cures cloudy eye, pop eye, body slime and mouth fungus.

Pimafix rapidly treats fungal infections on the body and fins, and internal and external bacterial infections.
All-Natural PimaFix treats fungal infections
Pimafix treats both internal and external bacterial infections
PimaFix has been formulated to work in combination with MelaFix to enhance effectiveness against fish diseases

University studies and laboratory tests showed that PimaFix is an effective antifungal AND antibacterial remedy for both freshwater and marine fish

Fungal infections may attack fish that have been damaged by rough handling, shipping, exposure to ammonia or nitrite, improper netting and malnutrition. Fungal pathogens use digestive enzymes to feed on fish tissue. These enzymes damage adjacent healthy tissue, allowing the disease to spread. Fungal infections are usually seen as white cottony patches on fish’s body and fins. Stressed or wounded fish are the most susceptible to fungal outbreaks.

Bacterial infections are also common, further weakening the fish and allowing the fungal infection to spread more rapidly. Left untreated, fish may die from disease and stress. Treatment should be administered as soon as possible to ensure quick recovery.

Why select PimaFix?
PimaFix is a natural botanical remedy made from Pimenta racemosa (West Indian Bay) oil, providing unique active compounds, which harmoniously work together to attack fish diseases. The active compounds found in Pimenta racemosa not only provide many different modes of action, but also eliminate the possibility of the development of resistant strains of disease-causing organisms. Until now, most antifungal medications resulted in unsightly water discoloration throughout the course of therapy.

PimaFix does not have this disadvantage, providing better viewing of fish during treatment. Treating with PimaFix will not harm the biological filter in freshwater or saltwater aquariums or ponds. PimaFix has no effect on pH. PimaFix is harmless to aquatic plants.

In extreme cases of especially stubborn infections, PimaFix has been designed to work synergistically with MelaFix. Using PimaFix and MelaFix together provides the added benefit of quick tissue regeneration and wound healing.
 
no every one else is fin i have a 10 gallon kinda heavily stocked but just till i get my 40 fixed....
2x cory
1xbumbleebee goby
1x 2in rainbow shark
1x2in horse face loach
1x angel and my poor pleco:(
and a some pea size snails

Your problem is your tank is grossly overstocked. There is not enough room for the fish to establish there own territory or really have room to even turn around. Expect more deaths unless you can correct the housing situation ASAP. I strongly advise against putting meds in your tank to try and correct the severe overstock problem. You need to test your water and do water changes as needed. While I do understand your 40 is getting fixed, this is to much stock to go in it as well. As a responsible fish keeper, you really should obtain appropriate housing, even if its only for a spare tank.
 
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