I have been known to use diatoms whenever I am messing about in the substrate - dividing old crypt clumps, thinning and re-setting Val, or (when unavoidable) when moving a sword. But I just run it on the water column. I don't see why it would not work equally well exhausting the build-up in conventional UG, but I have not done this myself. If you try and works, post back, that is good info.
RFUG should not build up enough mulm to justify it. If run w/o prefilters it might though- but again I have never done that myself. Since Penguins and their RFUG prefilter kits came on the market, that is all I have done with UG - and that is a long time now.