Another newbie here, I set my tank up in Jan. I have a 46g. bowfront w/ Rena XP2 canister and aragonite substrate. All were fine until I added black substrate and perhaps stirring the tank up caused one of my afras to become bloated. She has been like this for about 10 days. I feed them mini pellets on occasion, but Spirulina flakes are their staple. First, I did a major water change and a heavy dosing of epsom salt, waited 24 hrs and started Metra, finishing the second treatment yesterday. Is it ok to continue repeating the Metra until she is improved? The tablets I have are 250mg, 1 per 10g. I didn't isolate because I want to all the "bugs" in the tank, I have removed the carbon. My other fish seem fine and I'm feeding them lightly with metra treated pellets. I perform frequent water changes probably 25% every 10 days or so. The water parameters are safe with nothing alarming there. Is there a better approach? I prefer not to use Clout as I don't want to kill my Syno. Also, can anyone explain what gram-positive and gram-negative bacteria are?
3 Cynotilapia afra Jalo reef
3 Haplochromis Zebra Obliquiden
1 Labeotropheous trewavasae tumbi reef
3 Labidochromis caeruleus
1 Labidchromis sp. Srtk
2 Hemichromis bimaculatus
1 Melanochromis exasperatus
1 Metriaclima estherae
1 Metriaclima callainos;estherae
1 Metriclima Fainzilberi lundu
2 Neolamprologus Daffodil Brichardi
1 Synodontis Ocellifer catfish
I really appreciate any information to help my little fishy.

3 Cynotilapia afra Jalo reef
3 Haplochromis Zebra Obliquiden
1 Labeotropheous trewavasae tumbi reef
3 Labidochromis caeruleus
1 Labidchromis sp. Srtk
2 Hemichromis bimaculatus
1 Melanochromis exasperatus
1 Metriaclima estherae
1 Metriaclima callainos;estherae
1 Metriclima Fainzilberi lundu
2 Neolamprologus Daffodil Brichardi
1 Synodontis Ocellifer catfish
I really appreciate any information to help my little fishy.
