Thanks Jamie.
To everyone else, I agree. I knew that it could happen but the frog was bigger than the crayfish.. well it used to be. The crayfish has grown but was about the same size. Usually the frog wouldn't let the crayfish get close at all, he'd swim away. He could have been dead/dying, but I saw him swimming to the top to breath just about 45 minutes or so before.
But it could be she's going postal as pixl8r mentioned. Last night we found her eating a large mystery snail about twice it's size.
Do they get more aggressive as they get old enough to start developing eggs? I don't know how old exactly she is, but she was about a 1/2" - 3/4" when we got her about a month ago.
Lesson learned though. I'm setting up a 10gal just for the crayfish so no one else will be her meal. Hopefully she's getting close to developing eggs anyway and will be easier to keep them separated.