Yes, it is especially important for us to use a good water conditioner here. I hate that they even sell ones around here that don't handle chloramines and ammonia. Someone who doesn't know any better could get some really sick fish, and I am sure that happens. I was expecting the tank to be cycled since I brought over all the media from an old tank but I am getting ammonia, nitrite and nitrate readings. Just set it up a couple of days ago. I am doing frequent water changes with prime but also adding prime to the water a bit on its own. I see actual change from stressed fish to happy fish within like seconds of adding prime when i am dealing with a regular un-primed ammonia thing. I guess once the tanks cycle here the biological filter handles the ammonia from the tap water before the prime loses effect. But my ammonia readings are about 0.25-0.5. nitrites yesterday were 0 with a nitrates of about 10.The further reading that I have done shows that my binding assumption was incorrect. Prime does not bind by forming ammoniate complexes, but by reducing the ammonia (or chloramine) to a methenamine. This Compound can be broken down by a biological filter, and only can be converted back to ammonia under acidic conditions (outside of normal aquarium ranges). I guess that water changes would be a counterproductive way to reduce ammonia in your case.![]()