water changes to be done to suit your tank and fishes needs...if 50% a week works for you, then carry on. If you feel it is too much, then cut it down....there are advantages to cutting it down. As mentioned, temp, pH and hardness would be more stable, you wouldnt have to carry so much water around, the tank would get disturbed less....but i dont see any major problems with 50% a week, if you feel it is right.
if it would help, i'll let you know that i change 25% a month on my tank...some people would say that is far too little, but its what works for me and my fish. All the fish are healthy, water is crystal clear, water tests all com out good, excellent in fact. So its really what each individual tank needs.
Hope this helps.