I grew up in that neighborhood, so...
I grew up in Reedsport, Florence, and a little town called Port Orford, so that be my stomping grounds.
I would say the Newport Aquarium (where Keiko the Orca was kept) is definitely worth seeing, give it a good 4-5 hour visit. Also there is the University Marine Science Labs, if you are interested in Pacific Northwest marine life.
Further north, in Tillamook there is an aircraft museum made from an old dirigible hangar, a cool choice as well.
For sand dune buggy/ATV choices, I would suggest the north side of Coos Bay/North Bend, before crossing over the BIG bridge into town, a place called Horsfall Beach. Very cool. Or just south of Reedsport - Winchester Bay, has three beaches awesome for sand dune buggy/ATV action.
Would be glad for a few more pointers for ya, depending on your budget and wants.
Outside of Coos Bay is a drive called the Sunset Highway, which heads out of a town called Charleston along some awesome rocky tidepool areas, and ends in a place called Shore Acres - a botanical garden that is pretty cool. The garden once belonged to a large mansion estate that is no longer there (burned to the ground long ago I think) but the gardens are maintained as a part of the parks system.
What's yer gig, what's yer gag? Be glad to give you all sorts of pointers for eat spots, etc., everywhere from Florence south to Port Orford.