I have a penguin 330 and magnum 350. Both filters have seachem matrix in them and I was wondering If I were to put medication in my tank will it kill all the good bacteria in the matrix, also I was thinking about using both micron cartrige and carbon container for my magnum 350. I am thinking about using the micron cartrige after water changes( run for about 2 weeks) and then switch to the carbon media container that is filled with the seachem matrix. My next question is during the 2 week time that I am using the micron cartrige can I put the carbon container with the seachem matrix in a container of aquarium water to preserve the bacteria in it or will the bacteria all die?