I'm sorry things aren't looking well for your puffer.
I've always had good luck with FW Melafix. You could still try that, since you don't have a skimmer. Maybe that's part of your problem?
I'm sorry things aren't looking well for your puffer.I've always had good luck with FW Melafix. You could still try that, since you don't have a skimmer. Maybe that's part of your problem?
It does treat bacteria, and to a lesser extent parasites, but it is primarily effective against fungus, as are many sulfa/thia-based drugs. Stick with the ones I mentioned for now. Yes, there can be a maddening number of medications. I simply stick to the ones that I know work well most of the time.
Good luck and here's hoping that everything works out. You should still be seriously considering looking for a quarantine tank. Systemic administration orally works, but you need plenty of it, but a bath would be more effective as I already said, as well as others.